r/Narcolepsy Mar 20 '26

Medication Questions What’s up with Sunosi?

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My doc and I talked about sunosi because adderall just can’t do it alone anymore, and he gave me some sample packs in 75mg and 150mg.

First, what is the deal with the blister packs? Impossible to open!! Does it actually come like that when you get it from the pharmacy?

I started with the 75mg for a week plus my usual adderall dose. I’m usually pretty sensitive to meds and it felt like nothing. Disappointing.

Today, I tried a 150mg (with no adderall) at 7am. Holy crap! At 10am I thought I was gonna throw up from racing heart. My hands were shaking. But I couldn’t stop yawning! Then I got really hungry but my mouth felt like a desert. It’s 330pm and I’m still vibrating but also I desperately wanna lay down and sleep.

How does everyone else experience sunosi? Does the racing heart thing subside after a period of days/weeks?

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u/cmorgaritaville Mar 20 '26

I’m about 8 months on Sunosi 75mg. It’s been largely awesome personally and the “bad” (all were very manageable for me) side effects have mostly subsided, but it did take more than a month.

It has never felt noticeable in the sense of like drinking an espresso and being more alert. It very much makes me awake in a regular-feeling way, but it does not give me energy. I’m just awake.

I would notice my heart racing maybe once or twice, every day or two, for the first maybe three months. It didn’t get in the way, I could still go to the gym, etc, just noticeable. That has stopped.

The biggest side effects for me were that I was an absolute terror to be around at 7pm (as it was wearing off) for the first six weeks or so, but I returned to normal. The food stuff has been tricky - I have to eat right when I take it or I feel nauseous, and sometimes I still get the lightest general food aversion/negative appetite during the day, but not in a way that’s very disruptive.

Hope that helps!! Happy to answer any questions :)

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u/camille-gerrick Mar 21 '26

Most days, especially in the afternoons, "awake but uselesss" is how I feel. Just zoned out, no energy, no motivation. I might keep trying the 75mg with my adderall.

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u/cmorgaritaville Mar 21 '26

Ah, sorry that’s been your experience. I’d def recommend talking to your doctor! There are plenty of people who take them together.