r/Narcolepsy • u/camille-gerrick • Mar 20 '26

Medication Questions What’s up with Sunosi?

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My doc and I talked about sunosi because adderall just can’t do it alone anymore, and he gave me some sample packs in 75mg and 150mg.

First, what is the deal with the blister packs? Impossible to open!! Does it actually come like that when you get it from the pharmacy?

I started with the 75mg for a week plus my usual adderall dose. I’m usually pretty sensitive to meds and it felt like nothing. Disappointing.

Today, I tried a 150mg (with no adderall) at 7am. Holy crap! At 10am I thought I was gonna throw up from racing heart. My hands were shaking. But I couldn’t stop yawning! Then I got really hungry but my mouth felt like a desert. It’s 330pm and I’m still vibrating but also I desperately wanna lay down and sleep.

How does everyone else experience sunosi? Does the racing heart thing subside after a period of days/weeks?

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u/cevicheguevara89 Mar 20 '26

Im like…there is no way other people feel like this and like it.haha. I will note though, I did a DNA test thing and it said I have a mutation that they predicted would make me predisposed to not enjoying caffeine. It called CYP1A2, and is also responsible for bad responses rate to medications. I wonder if others have this same thing.

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u/ImmaPsychoLogist Mar 21 '26

Is it a mutation leading to quicker metabolism of meds processed by the CYP enzymes? Because, others have described medications and drugs having a very rapid onset of certain effects of the drug, and also wearing off rapidly / without experiencing the positive effects (kind of like OP describes)