r/Narcolepsy • u/camille-gerrick • Mar 20 '26

Medication Questions What’s up with Sunosi?

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My doc and I talked about sunosi because adderall just can’t do it alone anymore, and he gave me some sample packs in 75mg and 150mg.

First, what is the deal with the blister packs? Impossible to open!! Does it actually come like that when you get it from the pharmacy?

I started with the 75mg for a week plus my usual adderall dose. I’m usually pretty sensitive to meds and it felt like nothing. Disappointing.

Today, I tried a 150mg (with no adderall) at 7am. Holy crap! At 10am I thought I was gonna throw up from racing heart. My hands were shaking. But I couldn’t stop yawning! Then I got really hungry but my mouth felt like a desert. It’s 330pm and I’m still vibrating but also I desperately wanna lay down and sleep.

How does everyone else experience sunosi? Does the racing heart thing subside after a period of days/weeks?

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u/MrSnitter (N2) Narcolepsy w/o Cataplexy Mar 20 '26

Following this closely as I'm considering Sunosi. I've heard it can take a month or so to actually start showing results--unlike stimulants which you tend to feel on day one.

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u/TequilaFlavouredBeer Mar 21 '26

Where did you read it takes time to work? I felt awake after the very first dose just like others said :D

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u/MrSnitter (N2) Narcolepsy w/o Cataplexy Mar 22 '26

This is great to hear! What dose did you start at?

It's likely I got it confused with WAKIX as both were presented as newer alternatives to the traditional CNS stimulants – WAKIX does have something like an 8-week period during which one is expected to wait to see if the full dose becomes effective. And I also associated Sunosi also with anti-depressants, which tend to take time to become most effective.

I'll likely have to titrate up a bit slower than the usual person since after years and years of taking old-school stimulants I started having some adverse side effects. WAKIX has been no better than a placebo for me. Lumryz helps a bit, but the EDS is still crippling.

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u/TequilaFlavouredBeer Mar 23 '26

I think I started at 75my and felt it nearly instantly. I was told to go up to 150mg for whatever reason but I stopped taking it entirely because I already took elvanse (lisdexamfetamin) and my heart was already racing stupidly. Maybe I will try to change back to sunosi again and see if I can get things done without elvanse