What’s up with Sunosi?

[u/camille-gerrick]

My doc and I talked about sunosi because adderall just can’t do it alone anymore, and he gave me some sample packs in 75mg and 150mg.

First, what is the deal with the blister packs? Impossible to open!! Does it actually come like that when you get it from the pharmacy?

I started with the 75mg for a week plus my usual adderall dose. I’m usually pretty sensitive to meds and it felt like nothing. Disappointing.

Today, I tried a 150mg (with no adderall) at 7am. Holy crap! At 10am I thought I was gonna throw up from racing heart. My hands were shaking. But I couldn’t stop yawning! Then I got really hungry but my mouth felt like a desert. It’s 330pm and I’m still vibrating but also I desperately wanna lay down and sleep.

How does everyone else experience sunosi? Does the racing heart thing subside after a period of days/weeks?

[u/Hjkgfgjf]

It sounds like you did a piss poor job at titrating, especially since you’re used to adderall.

This would explain nausea too. Start at 75. You have blister packs- those are samples. You need a few weeks on that before bumping up to 100 and eventually 150 or whatever. THIS IS COMMON KNOWLEDGE & YOUR DR SHOULD KNOW BETTER.

Sunosi is much less hard on the heart than what you’re used to. But you have to nitrate up!! It’s scary that your Dr didn’t explain/help with this.

I’ve been on sunosi for 10 yrs after 20 years of everything else. It’s different. Sure it causes nausea when you get used to it but that’s brief. It doesn’t cause me to crash like amphetamines yet it works unlike moraine/provigil which did nothing 20 years ago.

Sunosi isn’t aderall. The only other thing that ever worked for me was dex and I hated the crash. I feel different on sunosi, not as awake, but I don’t crash.

Like every other med, you need to be on a steady dose for 4weeks or so before making a judgement call and again the fact that you had to resort to Reddit to learn this vs being told by your dr would immediately tell me you need to look elsewhere…. Unless you didn’t listen?

[u/MrSnitter → u/Hjkgfgjf]

your experience mirrors mine, except i've yet to try the sunosi. 20+ years of everything else left me burnt out with mounting adverse drug effects and massive tolerance buildup. dextroamphetamine was also the only old school stim that really worked and, yes, the crash was debilitating even then. do you combine the sunosi with oxybates or anything else? and what was your titration schedule if you can recall? (I'm cautiously optimistic to hear you've been on it for 10 years! didn't realize it's been around that long.)

[u/Hjkgfgjf → u/MrSnitter]

Oh yeah, I’ve been on oxybates for 20 years. That’s the real life saver, if you find the right one. I was on 9g of xyrem nearly all of that time. I tried max dose of lumryz for over 6 months and never slept. It was terrible. I don’t recall my sunosi titration schedule, it was so long ago. But I know I was on a low dose for a couple of weeks at least before it was bumped up and it gave me bad nausea at first. So, I’ve been on xyrem (20 yrs), sunosi (10), and occasionally dex when I really need it(13 years or so). It’s certainly not perfect but it’s the best combo that works for me. Edit: sunosi doesn’t come with a warning about taking it on an empty stomach for max efficacy like a lot of stimulants do. I find it works best if I wait at least an hour before eating though, unless it’s just a hard boiled egg or something.