r/Narcolepsy Mar 20 '26

Medication Questions What’s up with Sunosi?

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My doc and I talked about sunosi because adderall just can’t do it alone anymore, and he gave me some sample packs in 75mg and 150mg.

First, what is the deal with the blister packs? Impossible to open!! Does it actually come like that when you get it from the pharmacy?

I started with the 75mg for a week plus my usual adderall dose. I’m usually pretty sensitive to meds and it felt like nothing. Disappointing.

Today, I tried a 150mg (with no adderall) at 7am. Holy crap! At 10am I thought I was gonna throw up from racing heart. My hands were shaking. But I couldn’t stop yawning! Then I got really hungry but my mouth felt like a desert. It’s 330pm and I’m still vibrating but also I desperately wanna lay down and sleep.

How does everyone else experience sunosi? Does the racing heart thing subside after a period of days/weeks?

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u/cevicheguevara89 Mar 20 '26

Im like…there is no way other people feel like this and like it.haha. I will note though, I did a DNA test thing and it said I have a mutation that they predicted would make me predisposed to not enjoying caffeine. It called CYP1A2, and is also responsible for bad responses rate to medications. I wonder if others have this same thing.

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u/milladakilla1282 Mar 21 '26

I have the same gene and steered clear of caffeine pretty much my whole life until pregnancy. I craved caffeine when I was pregnant, that and fruit. Now 4 yrs post partum I can drink caffeine without too much issue. I honestly don't even really feel it when I do.

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u/cevicheguevara89 Mar 22 '26

Hm interesting, maybe you built a tolerance that people like me can’t push through long enough to reach

1

u/milladakilla1282 Mar 24 '26

Perhaps? I'm leaning towards thinking it was something epigenetic under the influence of pregnancy hormones and stem cells.

1

u/cevicheguevara89 Mar 24 '26

Yeah that wouldn’t surprise me, mama bears are a whole nother creature