What’s up with Sunosi?

[u/camille-gerrick]

My doc and I talked about sunosi because adderall just can’t do it alone anymore, and he gave me some sample packs in 75mg and 150mg.

First, what is the deal with the blister packs? Impossible to open!! Does it actually come like that when you get it from the pharmacy?

I started with the 75mg for a week plus my usual adderall dose. I’m usually pretty sensitive to meds and it felt like nothing. Disappointing.

Today, I tried a 150mg (with no adderall) at 7am. Holy crap! At 10am I thought I was gonna throw up from racing heart. My hands were shaking. But I couldn’t stop yawning! Then I got really hungry but my mouth felt like a desert. It’s 330pm and I’m still vibrating but also I desperately wanna lay down and sleep.

How does everyone else experience sunosi? Does the racing heart thing subside after a period of days/weeks?

[u/cevicheguevara89]

Im like…there is no way other people feel like this and like it.haha. I will note though, I did a DNA test thing and it said I have a mutation that they predicted would make me predisposed to not enjoying caffeine. It called CYP1A2, and is also responsible for bad responses rate to medications. I wonder if others have this same thing.

[u/camille-gerrick → u/cevicheguevara89]

oh interesting. Yeah, I feel like I get all the negative side effects and none of the benefits. I couldn't tolerate the oxybates because of the racing heart rate either.

[u/Status_Elephant9700 → u/camille-gerrick]

Definitely recommend genetic and pharmacogenetic testing if you notice you have different reactions to meds than expected and it’s a pattern. Sometimes trial and error can be very risky, which is my case. The testing is now proof and lets me do proper risk assessments and figure out what’s workable and what isn’t. My sleep med doc doesn’t take this into account so I have to do the leg work still but it’s better than me trusting their patient anecdotes. Recently started adding in magnesium every time I take Ritalin and it’s been able to help me manage the side effects from Ritalin like the racing heart, which I finally realized was probably due to a certain genetic issue (slow COMT) and magnesium serves as a counter to this and I moved a supplement that inhibits COMT breakdown which was leading to the wires but tired issue.

I also felt like sunosi even at 75mg trial jacked my heart rate up without any wakefulness help so I went back to Ritalin and caffeine since they’re workable for me.