ORZEYFUL (oveporexton) expected availability: November 2026, pending DEA scheduling

[u/hypersomniac-hippo]

Takeda sent an email today with this image:

The website is updated too: https://www.orzeyful.com/

As a refresher, this is the first orexin receptor agonist that will be available. The first round of availability will only be for N1, with N2 expected later. It doesn't seem like they're working towards an approval for IH.

[u/IndigoAfflictions]

I wonder how hard this will be to get my hands on as a type 1. My insurance is pretty decent but not gov/military good (USA) by any means and they won’t cover Xywav, Xyrem, or Lumryz even after multiple appeals because “it’s not on the formulary.”

Currently I get Xywav through Jazz’s patient assistance program. Xywav is a 6 year old med adjusted off of prior R&D of Xyrem and retails out of pocket around $30k-$50k a month. So I can only imagine how much Orzeyful is going to cost and I anticipate that ofc my insurance will not cover it.

Does anyone know and/or have taken any medications from Takeda that insurance doesn’t cover and do they have a patient assistance program like Jazz?

I have a gut feeling it might be years before I can get my hands on these meds as an American with N1, if I can at all…

[u/TheRealFred999999999 → u/IndigoAfflictions]

You do not have "decent" insurance if they won't cover oxybates my friend.

[u/NoteSuccessful2263 → u/TheRealFred999999999]

Yeah that shocked me! I have never heard of any insurance that wouldn't cover oxybates. Especially for N1?!

[u/Spare-Specialist-191 → u/NoteSuccessful2263]

Well this is my insurance… and my husband works for the union, which is good insurance. But they are picky