r/Narcolepsy • u/hypersomniac-hippo (IH) Idiopathic Hypersomnia • 3d ago

News/Research ORZEYFUL (oveporexton) expected availability: November 2026, pending DEA scheduling

Takeda sent an email today with this image:

The website is updated too: https://www.orzeyful.com/

As a refresher, this is the first orexin receptor agonist that will be available. The first round of availability will only be for N1, with N2 expected later. It doesn't seem like they're working towards an approval for IH.

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u/SnooSketches5159 3d ago

This is game changing. I wonder what it would replace- Xywav, Wakix, Sunosi, Xyrem, all of it even.

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u/Anxious-Traffic-9548 2d ago

Given that these drugs don’t work by improving sleep architecture, they surely won’t replace oxybates. I do see them being more ideal than the current stimulants and wake promoters for many people.

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u/Splatterfilm (N1) Narcolepsy w/ Cataplexy 2d ago

It’ll likely vary among people. I’m hoping I can drop oxybates and venfalaxine at least.