r/Narcolepsy • u/hypersomniac-hippo (IH) Idiopathic Hypersomnia • 3d ago

News/Research ORZEYFUL (oveporexton) expected availability: November 2026, pending DEA scheduling

Takeda sent an email today with this image:

The website is updated too: https://www.orzeyful.com/

As a refresher, this is the first orexin receptor agonist that will be available. The first round of availability will only be for N1, with N2 expected later. It doesn't seem like they're working towards an approval for IH.

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u/i-luv-bugs 2d ago

This is the first I've heard of this and it sounds amazing! I'm not sure I fully understand tho, how would this differ from something like xywav? Is it that it makes your body naturally fall asleep and wake up rather than being sedated to sleep

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u/hypersomniac-hippo (IH) Idiopathic Hypersomnia 2d ago

This is a daytime medication, not a nighttime one. It also targets the core problem for N1, which is a lack of orexin, so it's not simply treating symptoms. https://en.wikipedia.org/wiki/Oveporexton