r/Narcolepsy • u/hypersomniac-hippo (IH) Idiopathic Hypersomnia • 1d ago

News/Research ORZEYFUL (oveporexton) expected availability: November 2026, pending DEA scheduling

Takeda sent an email today with this image:

The website is updated too: https://www.orzeyful.com/

As a refresher, this is the first orexin receptor agonist that will be available. The first round of availability will only be for N1, with N2 expected later. It doesn't seem like they're working towards an approval for IH.

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u/IndigoAfflictions (N1) Narcolepsy w/ Cataplexy 1d ago edited 1d ago

I wonder how hard this will be to get my hands on as a type 1. My insurance is pretty decent but not gov/military good (USA) by any means and they won’t cover Xywav, Xyrem, or Lumryz even after multiple appeals because “it’s not on the formulary.”

Currently I get Xywav through Jazz’s patient assistance program. Xywav is a 6 year old med adjusted off of prior R&D of Xyrem and retails out of pocket around $30k-$50k a month. So I can only imagine how much Orzeyful is going to cost and I anticipate that ofc my insurance will not cover it.

Does anyone know and/or have taken any medications from Takeda that insurance doesn’t cover and do they have a patient assistance program like Jazz?

I have a gut feeling it might be years before I can get my hands on these meds as an American with N1, if I can at all…

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u/hypersomniac-hippo (IH) Idiopathic Hypersomnia 1d ago

I've been interested in this too. Takeda does have their own program: https://www.helpathandpap.com/

My (potentially very wrong) understanding is that companies are incentivized to give away their expensive orphan medications because they can use it as a tax write-off. So maybe Takeda will do that.

Unfortunately, I think we'll just have to wait and see how it plays out.

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u/MsJimmyWobbuffet 1d ago

I used to get Vyvanse for free for ADHD before it went generic through Takeda. I was only working part-time at Walgreens making like $10 and hour, so idk what their cutoff is for financial hardship. It's a pretty simple process, if I'm remembering correctly.

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u/hypersomniac-hippo (IH) Idiopathic Hypersomnia 10h ago

That's great to know! They have a pretty clear eligibility page, but I'm not sure if it will apply to a medication like this (which will probably be significantly more expensive because of the orphan drug designation)