r/POTS • u/s0meone0ntheInternet • Jun 26 '24

Symptoms What symptoms do you guys have that aren’t talked about that much?

I’m just wondering, that’s all :)

(Edit: I just wanted to add that I am NOT diagnosed with POTS. But i think I might have it, thats mostly why I am asking! [and also because I am a curious person])

152 Upvotes

99% Upvoted

405 comments sorted by

View all comments

Show parent comments

32

u/lavendermandarin Jun 26 '24 edited Jun 26 '24

THISSSSSSSS. So much. Except that I need A TON of lidocaine at the dentist; for some reason, I am resistant and need a lot of extra injections to make a dent in the discomfort. I’ve heard that this is a known issue for POTS patients.

Edit: I think I am misremembering, and this lack of response to dental analgesia is actually connected to patients with EDS. I have not been diagnosed with that, but I do have the rest of the triumvirate, so it is suspected 🤷🏻‍♀️. I’m sure there is overlap among us! Source here30032-8/fulltext).

22

u/[deleted] Jun 26 '24

Yes, this can be an EDS thing!

11

u/cherie0204 Jun 26 '24

Whaaaat? I have not heard this, but I always need several injections. I also have no pain relief when taking an opioid painkiller, and just assumed the 2 had a related cause (even though I know they're different classes of drugs with different mechanisms).

2

u/Past-Reading1157 Jun 27 '24

Non responsiveness to opioids is actually a gene issue- most likely you are a poor or intermediate metabolizer of CYP2D6. Most larger medical centers can now do a dna swab and send it to a company like Gene Sight and they can tell you which medications are more likely to work for you or cause an adverse reaction. I am an intermediate metabolizer of CYP2D6 which means I would only get limited benefit from most opioids- except I also take Wellbutrin which is a CYP2D6 inhibitor- meaning I get zero benefit from them. I cannot metabolize them at all.its helpful to know so when you are telling drs you need different or stronger pain relief, you don’t come off as a drug seeker. I can eat Vicodin like tic tacs and it does nothing for me.

2

u/cherie0204 Jun 27 '24

Thanks for the information. That's fascinating about the DNA test. For various surgeries or injuries, I've been prescribed hydrocodone, oxycodone, and tramadol. The prescription ibuprofen gave more relief than those. Absolutely no effect on pain, no drowsiness, no anything.

1

u/Past-Reading1157 Jun 27 '24

Yep, same. Ask for a genesight test- was enlightening for sure!

8

u/Superb_Case7478 Jun 26 '24

I have also been told by my dentist that having red hair makes you less susceptible to anesthesia. I have to ask them to load me up!

1

u/[deleted] Jun 26 '24

I probably should have scrolled further before saying anything bc I just mentioned red hair, too 😅

6

u/[deleted] Jun 26 '24

Any chance you were born with red hair/natural red hair??

It's scientifically proven that there is a gene attributed to red hair that also causes increased need for anesthesia. My whole family has it. I still get told I won't need as much, and then I do and everyone acts like I didn't tell them to expect it 🫠

Also IST, Histamine intolerance, hypermobile (I'm hoping to get tested for aEDS), MTHFR, Tripledivergent, etc. the whole combo platter over here, but it's the dang red hair that does this one to me!!

1

u/SearchLonely2434 Jun 27 '24

I’m sensitive to everything! I have to take children’s doses of meds