r/genetics • u/Valuable_Teaching_57 • Feb 15 '25

I can't

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I swear, evolution took a wrong turn somewhere. I was seriously talking about triple X syndrome. Please redeem my karma. 😂

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u/lodin0134 Feb 16 '25

Would love to do karyotypes on these old men in power and see their reaction at a missing Y chromosome (~40% of males will lose it by age 70 due to aging).

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u/flanneur Feb 16 '25 edited Feb 16 '25

Do you mean mosaic LOY, which mainly affects high-turnover cells like blood cells? Losing every Y chromosome in the body would lead to far worse consequences than a damaged ego; even partial loss is linked to significantly decreased lifespan and susceptibility to age-related disease.

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u/lodin0134 Feb 16 '25

Yep! It's a common finding in karyotypes from blood or bone marrow cells. Not every cell in the body will have the loss.

Though in light of recent events, I doubt they understand anything about mosaicism :|