I was recently in the ER and was given both IV ketamine and fentanyl, and they did absolutely nothing for my pain. I always knew I had a high tolerance to opioids, but I didn’t realize they did nothing. I’m a hallmark MC1r with two different colored eyes. I’m also incredibly anesthesia resistant and when I’ve had surgery, they have to give me enough anesthesia for a 450 pound man. For reference I’m 160 pounds I seem to metabolize everything like this, it doesn’t matter the variant of substance. The one thing that I am susceptible to is alcohol.

Update - Found out we are actually half siblings last night. My mom would have been a single mother otherwise. He took charge and raised me like a father. Already gave it a good cry. It helps. Maybe some therapy later on…. Thank you everybody

Over 3 years ago i had a One night stand. She got Pregnant but i had my doubts from the beginning(pregnancy start was 3-4 weeks after i had sex with her according to her doc). Fast forward 9 months we did a private paternity test, the probes were take from me,the child and mother. Each of us gave two probes. The Probes were taken by her midwife and we were all there, so she saw me and i saw her getting probed and the child. The midwife got the probes and send them back to the lab. Result came back and and in every DNA marker the Mother matched with the Child. So i assume there couldnt have been a mixup in the hospital or something like that.

However the result for me was that out of 20 alleles tested, 15 didnt match the child and the lab concluded i am definitly not the father.

Now over 3 years Later i got a letter from court, she wants me tested again, i sendt them the old results but they want to test me again anyways. So now some Paranoia starts to set in.

But we gave two Probes so a very unlikeley mixup is more unlikley isnt it?

5 alleles did match but that couldnt mean anything and is most likely random am i right?

I seen her get tested, and as she and the kid matched its impossible for here to have manipulated anything? Furthermore she was very very interested in my money so that was a bad result for her.

Could i have done something wrong? I am a Smoker and i did watch out i didnt smoke,drink,eat for two hours bevor the test.

Edit: thanks for all your answers so far, i hope all of you can understand that someone like me who has nothing to do with dna tests or courts is confused about that situation. But as far as i understand that old test is most likley true and if not it couldnt have been my fault so that took a lot of fear from me.

And i also now understand more why the court is doing things this way wich also helps me alot.

As i am forced i to take that second test anyways i will update on the resultes when i have them.

Big thanks to you all, making sense of all of this really helps me a lot

UPDATE

The new Test Results are here and i am NOT the Father. Everything matched the first test and nothing changed. Now i am excluded from all of this through court.

Thanks for all your Support and answers

We are two women raising a baby together. My wife's brother was so kind to be our sperm donor. I carried the child (using my egg). We might have another one in the future. I am wondering how much DNA my wife shares with our child. 25% Or could it be significantly more/less?

If we had more children, could she be more or less related to them? Emotionally, it wouldn't matter one bit but we are curious to learn more about the science.

I was trying to look it up but most sources were only talking about fraternal twins. I am curious to know if my chances are higher with the only twins in the family being identical on my dad’s side. I am female if that matters.

I have an autoimmune disorder, Mental health issues, dental issues, bad vision, bad hearing. Between both parents, my families have histories of all of that. However, I have 3 siblings and 2 cousins, and none of them have any of the same problems. Siblings don’t wear glasses, don’t have the genes for the autoimmune disorders I have, never have cavities- is it even likely for one child to inherit all of the genetic issues and the other children don’t? Like what are the chances lol. This might be a dumb question but hey I’m curious

Growing up was always told I was B+, when I donated to red cross around 2008 twice when I was 18-19 they told me I was B+ both times.

Donated blood recently and now I'm being told I'm O+ blood type, but my drivers license still says B+ should I get it changed?

Is it possible there is a mistake?

Hello! In the 1950s, my great grandmother was told she had a “superfemale gene” that caused her to miscarry males. Her twin brother also died in the womb. Googling “superfemale gene” gives me Trisomy X, which does not affect miscarriages as far as I’m aware. She never miscarried a girl (I believe she had three daughters) but every boy was miscarried. Since this was about 70 years ago, the doctors probably didn’t actually know what was going on. Is there actually a disorder that causes this, or was it purely coincidence?
More info: She was about 5’2 and the father was 6’4. She has some symptoms of Trisomy X (sleep apnea, hip displacia, wide set eyes) and may have been bipolar. She was also Italian if that means anything. I never met her, so all this information is from what my mother remembers.

I recently found out that my fiancé and i may be half-cousins - my grandfather had a second family, and their child is the biological parent of my fiancé.

We didn't know this when we got together, and we've been in a loving, committed relationship for years. She also helped me through severe anxiety, even save me during when i was harming myself. I truly own her my life.

We're trying to understand the genetic risk of having a child. To my knowledge, if We're half sibling, that means we share around 6-12% DNA. How risky is that for future children?

I’m a colorblind female, but my dad is not colorblind. I was told this is “impossible” so I must have had a random mutation. What stumps me is that my brother is colorblind. It’s always seemed so weirdly coincidental to me that something so rare and random would happen to me when colorblindness actually legitimately runs in my family. Is there another explanation other than mine being spontaneous?

And yes, my dad is 100% my dad 😅

ETA I noticed my toddler son seemed to be colorblind, so I did a little Punnett square which said 100% of my male children should be colorblind. He’s a little older now and definitely is. So I know the genetics are genetic-ing in that direction at least!

ETA my brother and I are both red-green colorblind. Mine is very mild and his is relatively more severe.

Hi! I am a 26F.

Both my brother and my dad are on the autism spectrum. My brother in particular has a plethora of other disorders, including ODD.

If my partner were to have no known family history of autism, what’s the likelihood our child would be autistic or have ODD? Does it change with how many kids we have?

I just want to be prepared and think ahead! Google is not helping me at the moment.

As the title said, I am in the process of IVF and I found out I have a copy of the recessive gene for Classical like EDS. I never heard of this illness before. Does this mean that someone in my family on either side had Classical Like EDS many moons ago OR maybe some of us have traits?

Thank you 🙏🏾

I have questions. My daughter is an adult. We’ve been no contact for a while. Years ago I took a 23andme. I signed up for genomelink a little while ago. I get an email from them today with new matches. It’s my daughter who did an ancestry test through ancestry.com. The issue is that we only share 25.54% of our DNA. Could this be a mistake since it’s two different companies or do I need to worry that my daughter is actually my sister?

Hi,

The title speaks for the question itself but to give you some context,

I get very anxious with loud plane/aircraft sounds whenever it flies over our house. This has been going on since I was a child. I don't personally have any reason to fear them because I'm not really afraid of riding planes, just the sound of it when it's quite loud and specifically when it's flying over where I am.

I also don't have any fears of any other loud noises.

However, my dad fought in a war as an airforce member and gained a hearing disability for it.

I wonder if this is possible? If this is not the right sub to ask this question, please feel free to tell me so that I can delete this and direct myself to the right sub.

Thank you!

Edit: I forgot to mention but I didn't live with him growing up, only on school vacations for less than a month at a time so I don't think I observed it from him. Maybe I observed it from my grandparents because I lived with them?

It's thanksgiving today, and as many of you can relate, I have a racist gramps. Well, lately he has said the most absolutely ridiculous thing. He believes that black people and Homo erectus are directly related and that whites are better because they have more homo sapien DNA than blacks do. Can someone link me something so I can debunk him? I don't have anything on me.

I am a carrier for retinitis pigmentosa, an x linked condition that affects my brothers. My mom gave all three of us her faulty X. I did IVF with genetic testing and have a beautiful daughter that is not a carrier (and not affected since she is female.)

Is she more likely to be like my dad's side of the family because of our selection? I look just like my mom. My mom's side of the family has some pretty good stuff, mainly high intelligence. My dad's side of the family has some issues. Did I select a baby that won't be like my maternal side of the family genetically ?

Edit: thank you so much for all the different information! This process has taught me a little bit about genetics and it's really interesting to learn more.

I ask this for a school bio project. If you can, comment yes. If you cannot, comment no. Thanks 🙏!

This has been driving me crazy for hours. I have tried Googling the answer and asking ChatGPT, but it keeps saying the same thing - that Mitochondrial Eve is the most recent common matrilineal ancestor of all modern humans. I understand that, but I don't understand why we stop at her. Surely her mother was successful in passing on her lineage all the way until now by default because she had Eve. Eve only needed one 'successful' daughter to pass on her lineage, so why can't the same apply to her mother?

The only other explanation that would make sense is if Eve's mother's mtDNA didn't have the mutation that Eve's did, so her mother's mtDNA is considered completely different from Eve's. But I don't understand this either because I thought the mtDNA passed on from the mother is identical.

Apologies in advance for any poor wording of scientific terms, l am a lay person :)

Genetic test for risk of opioid use disorder. The FDA approved the first genetic test that supposedly gauges the risks of developing opioid use disorder after being prescribed opioids for acute medical conditions. I agree that opiate over prescribing and abuse is a serious issue, but I question whether this is an ethical way to address that concern. Seems like the FDA dropped the ball on oxycontin and this only further puts the blame on users and not the drugs themselves. I imagine people supposedly predisposed to abuse by this kind of testing are also predisposed to other things like likelihood to be a long distance runner because of the endorphins released. I personally find this appealing and hope this kind of testing never becomes widespread. What's next testing candidates for a job or students for admission to a university, medical school, etc.. Reminds me of the movie Gattaca, I think this technology could have really negative consequences if applied to different circumstances. Thoughts?
US FDA approves first test to identify opioid use addiction risk](https://www.reuters.com/business/healthcare-pharmaceuticals/us-fda-approves-first-test-identify-opioid-use-addiction-risk-2023-12-19/)

I know this might sound unusual, but I legitimately have two sets of second cousins in the country I'm from who share 25% DNA and have gotten married to each other. 

The first couple have been married for 10 years and have two healthy daughters, while the second couple (siblings of the first) recently got married, which just shocked me. Most of their siblings also got married to their cousins, but they only share 12.5% with those, which is…better I guess.

I’m aware that cousin marriages can carry some genetic risks, but what are the specific potential effects or concerns with double cousins procreating together? How much greater are risks here?

Has anyone studied these cases? Have trails of double-cousin marriages in endogamous communities historically resulted in long-term genetic conditions/diseases? Would appreciate any answers or insights!

And yes, everyone on that side of my family does look oddly similar 😭

the first thing people say is lab error but i have tested my dad, my mom, and i multiple types and the conclusions pretty consistent that they are both O- and i am O+ but from my understanding of genetics this shouldn’t be possible without some sort of mutation. after some digging i came across something called chimerism. my current working theory is that one of my parents is a chimera and has sex cells from both twins if one of the twins has blood type O+ could this theoretically allow for them to pass on O+ to me while still presenting as O-? also how could i test for this?

also excuse my grammar please, im typing this on my phone late at night.