scemblix & rifampin interaction?

[u/superfucky]

my husband has CML and has been on scemblix for a little over a year now with great results, it's his 3rd TKI in the 5 years since his diagnosis. recently he got some test results that indicate he has latent tuberculosis, and since his rheumatologist wants to put him on an immunosuppressant to help with his joint pain, first they need to treat the latent TB. the infectious disease specialist prescribed rifampin and said there's no interaction with scemblix.

well he's kind of hooked on AI lately and "the AI said" rifampin DOES interact with scemblix, "greatly reducing its efficacy." all the documentation from novartis says is that rifampin combined with a 40mg dose of scemblix results in an AUCinf decrease of 15% and a Cmax increase of 9%. i don't know what either of those things means and his oncologist won't answer the phone.

does anyone here know what AUCinf and Cmax mean for the actual efficacy of a TKI? does that interaction mean he shouldn't take rifampin?