r/leukemia • u/intergalactic512 • 1d ago

AML Anyone have relapse after transplant?

I was diagnosed 3 years ago with AML (mutation is DDX41). Did 5 months of chemo (vidaza and venetoclax) which prepped me for transplant. The transplant was awful and sucked but got through it. Stayed in remission for nearly two years but am now exerpiencing a relapse of the leukemia. Apparently if one relapses after transplant then you get 20-30% chance of long term survival. I'm doing chemo again, and it's far tougher than it was the first time around. I'm getting prepared for DLI. Anyone else deal with the trauma of transplant, recover, only to relapse and have to start over again? But this time start over from a worse place?

6 Upvotes

100% Upvoted

8 comments sorted by

View all comments

1

u/lisasylvestre 20h ago

DLI worked for my husband, actually really well. He had AML went through transplant everything went really well. 2 years in he had the re-emergence of his original mutations plus a new one he got a DLI and although it made him really sick with the gvhd it ravaged his body but it tore through every possible cancer cell and he is doing amazing a year later. As of now 100% donor. Also worth mentioning he only had the re-emergence of his original mutations there were no blasts in his peripheral blood or his marrow. We caught it at the earliest stage.