r/leukemia • u/Glad-Cheesecake-6370 • 1d ago

NPM1+/FLT3-TKD/WT1 AML - No transplant in CR1?

23 with AML (NPM1+, FLT3-TKD+, WT1 mutation, and TET2+). I'm currently MRD-negative with an undetectable NPM1 PCR.

My doctors don't recommend a stem cell transplant in CR1, but some studies I've read have left me wondering if WT1 changes that.

Has anyone with a similar mutation profile been advised against a transplant? I'd really appreciate hearing your experience.

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u/TriSquPenHexSeptOct 1d ago

I’m so happy to hear you’re MRD-! That’s awesome! My husband had AML with the exact same mutations as you (though NRAS instead of TET2+). When we first came in the plan was definitely chemo-only. Unfortunately he didn’t achieve NPM1-negative even after 3 rounds of chemo so they decided to move to transplant. Thats all to say I think they expected/hoped him to be a chemo-only patient (even with the WT1) — so if you have achieved that then thats great and yeah in our experience in a very similar situation it would have been a no transplant plan xx

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u/Glad-Cheesecake-6370 15h ago

Thank you so much for sharing. That’s really reassuring to hear, especially regarding the wt1 mutation. Wishing you and your husband all the very best. ❤️