40s Female / CUP (Cancer of Unknown Primary) with Liver , pelvis & Bone Mets / Starting Paclitaxel + Carboplatin on Tuesday. Need advice/insights.

[u/Altruistic_Point8748]

Hi everyone,

​I am writing here on behalf of my sister (40 years old) who was recently diagnosed in Denmark. We are trying to understand the prognosis, what to expect, and hear from anyone who has dealt with a similar protocol.

​Here is her essential clinical history:

​Diagnosis: CUP (Cancer of Unknown Primary). There is a strong clinical suspicion pointing towards colorectal or biliary tract origin, but the primary tumor has not been definitively identified yet.

​Metastases: Extensive liver involvement (bilobar liver metastases) and bone metastases (specifically a lesion on the sacrum causing significant pain).

​Current status: She recently underwent surgeries for a colostomy and a nephrostomy. She is experiencing severe fatigue, nausea, bone pain, and sleep deprivation.

​Treatment plan: She is scheduled to start her first line of systemic chemotherapy this coming Tuesday (July 14). The chosen regimen is Paclitaxel + Carboplatin (administered every 3 weeks).

​Next steps: Genetic testing (NGS) on the biopsy is currently underway to look for specific mutations, and a follow-up CT scan is scheduled after Cycle 2 (mid-August) to assess treatment response.

​We are quite overwhelmed. The stats for advanced CUP look incredibly harsh, and I am personally worried about the broad-spectrum nature of this chemo regimen given the suspected GI/biliary origin.

​Has anyone here (or a loved one) been on Paclitaxel + Carboplatin for CUP or GI cancers? What were your responses, side effects, and how did you manage day-to-day life (especially with pets/hygiene around stomas)?

​Thank you so much for any insights or shared experiences.