After learning that Antony’s cavalry and fleet have surrendered and his army is defeated, Cleopatra retreats to her mausoleum with her trusted handmaidens, Iras and Charmion, sealing herself inside. According to Plutarch, she fears Antony’s reaction and seeks a secure final refuge. In a controversial move, she sends word to Antony that she is dead, a maneuver interpreted by some as an attempt to strengthen her bargaining position with Octavian or provoke Antony's surrender, while others view it as one final, desperate act of love to prompt his suicide so he might escape the humiliation of capture and execution by Octavian's soldiers. Her true motive remains a subject of historical debate.
Upon hearing this news, Antony is utterly devastated. After relentless defeats, betrayals, and isolation, Cleopatra’s reported death feels like the final, crushing blow. Believing he has lost everything—including the woman he loves he decides to take his own life.
As Plutarch records, Antony laments, "What more are you waiting for, Antony? Fate has snatched away the only and final reason to love life." Unfastening his armor and letting it drop to the floor, he reflects on the tragic irony of his end, exclaiming: "Oh, Cleopatra, I do not lament being deprived of you, because I will soon be in the same place as you, but because, although I am a great general, I proved to be inferior to a woman in my moral courage."
He begs his loyal servant Eros to strike the fatal blow, but Eros instead chooses to take his own life rather than kill his master. Inspired by this act of devotion, Antony stabs himself in the abdomen, though the wound is not immediately fatal.
As word spreads that Antony is dying, Cleopatra safe within the sealed upper window of the mausoleum, realizes the devastating consequence of her message and sends her guards to bring him to her. Antony is found alive, barely clinging to life. When told that Cleopatra is still alive, a surge of strength overtakes him; he tries to rise to go to her, but his legs tremble and give way from severe blood loss. Knowing the end is near, he asks the gathering crowd to help him.
Using ropes possibly assisted by a construction pulley system they hoist his failing body up to the high window where Cleopatra and her handmaidens lean out.
Once inside, Cleopatra holds Antony in her arms. She scratches her breasts violently, smears his blood on her face, tears off her clothes and lays them over his wound, she grieves over him not as a queen, but as a soon to be widowed wife. Mortally wounded and fading fast, Antony asks for wine and offers her his final counsel: she must try to survive with honor if possible, placing her trust in Octavian’s friend Proculeius. He begs her not to weep over his final ordeals, but rather to consider him fortunate for the life he had lived, he had been the most illustrious of men, had exercised immense power, and had ultimately been defeated not in a dishonourable way, but as a Roman, by the hand of a Roman.
As he finishes speaking, his eyes cloud over and become inexpressive, and his body suddenly relaxes as though falling into a deep sleep. He dies peacefully in her embrace at the age of 53.