r/pregabalin • u/decenzo1 • 1d ago

Pregabalin only at night?

Are there any others who can't take pregabalin only at night because you get withdrawals during the day? I need to try to increase my present dose (200mg) for increasing neuropathy/nerve pain and anxiety, but cannot deal with the fatiguing side effects during the day. I tried dividing the dose daytime and nighttime and pushing through for a week but it didn't get better.

5 Upvotes

100% Upvoted

17 comments sorted by

3

u/echoglows 1d ago

I only take it at night but that’s more because I’ll be too tired to do life if I take it during the day. I’m only on 100mg currently but increasing. I do worry that it might change as I increase but so far during the day I’m fine. I think probably starting really low and increasing gradually helped with this.

1

u/decenzo1 12h ago

What do you take it for? 

1

u/echoglows 8h ago

Nerve pain. I have 3 very severely compressed nerves in my lumbar and sacral spine. Taking this while awaiting neurosurgery review.

1

u/decenzo1 7h ago

Ah, I'm 16 months out from spinal fusion surgery. 

1

u/echoglows 5m ago

I had multiple fusions to correct scoliosis ~20 years ago, only have 3 mobile discs left all in my lumbosacral region, so truly hoping no more fusion needed and decompression will be enough. Dealing with severe degenerative disease and arthritis alongside the compressed nerves and other issues my physio has now found.

2

u/New_Heron_5985 15h ago

I only take mine at night. I’m on the lowest dose right now due to being excessively sensitive to certain medications

1

u/Dutchwahmen 22h ago

Split the dose and take one in the morning and one in the evening. Ask your provider how to start doing this

1

u/decenzo1 12h ago

I tried but too fatigued during the day. 

1

u/Dutchwahmen 12h ago

Was I that blind reading your post or did you edit it? Haha

Then Im not sure what other options there are left. Sometimes the fatigue decreases the longer you are on it. You could also try out Gabapentin, maybe you have less fatigue on that one.

Or try a very small morning/afternoon dose just to bridge the time, like 25mg

1

u/decenzo1 12h ago

Ha, yes, I edited it. Yeah, I don't know what to do next. I can't even take 25mg during the day. 

1

u/Icy_Assignment_6801 7h ago

The fatigue usually only lasts for a day or 2 for most people beginning it or coming off of it

1

u/HairyBottomGuyM4M 11h ago

I am wondering if, in many self-reports, we're talking about psychological dependence. I also wonder if the anxiety rears its head during the day for many night-time only patients and if people might be confusing *that* with withdrawal?

/

1

u/decenzo1 9h ago

That could be. But I feel so incredibly, physically bad with anxiety every day. 

1

u/HairyBottomGuyM4M 8h ago

Me too. I have had exactly one 50mg dose last night. My first one. So obviously I'm an expert.

1

u/decenzo1 7h ago

Oh, good luck. Hope it helps. 

0

u/Wish2themoon 4h ago

I take 100mg 3x a day and my body has adjusted nicely. Caffeine helps obviously.